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Hspa1l Gene Detail
Summary
  • Symbol
    Hspa1l
  • Name
    heat shock protein 1-like
  • Synonyms
    70kDa, Hsc70t, Msh5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96231
    NCBI Gene: 15482
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35191679-35198204 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.51 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96231
 protein coding gene Chr17:35191679-35198261 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023603
 protein coding gene Chr17:35103189-35110089 (+)
A/J MGP_AJ_G0023563
 protein coding gene Chr17:33947456-33953907 (+)
AKR/J MGP_AKRJ_G0023531
 protein coding gene Chr17:34412264-34420419 (+)
BALB/cJ MGP_BALBcJ_G0023569
 protein coding gene Chr17:34076253-34082630 (+)
C3H/HeJ MGP_C3HHeJ_G0023330
 protein coding gene Chr17:34809512-34817355 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024008
 protein coding gene Chr17:36442162-36451465 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021489
 protein coding gene Chr17:31715715-31722149 (+)
CAST/EiJ MGP_CASTEiJ_G0022827
 protein coding gene Chr17:34813839-34820513 (+)
CBA/J MGP_CBAJ_G0023308
 protein coding gene Chr17:37950038-37959224 (+)
DBA/2J MGP_DBA2J_G0023435
 protein coding gene Chr17:33264140-33271439 (+)
FVB/NJ MGP_FVBNJ_G0023403
 protein coding gene Chr17:33100538-33107088 (+)
LP/J MGP_LPJ_G0023513
 protein coding gene Chr17:35433293-35439746 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023425
 protein coding gene Chr17:36884544-36891065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024053
 protein coding gene Chr17:34622489-34644212 (+)
PWK/PhJ MGP_PWKPhJ_G0022574
 protein coding gene Chr17:32091716-32098527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022394
 protein coding gene Chr17:32639192-32650217 (+)
WSB/EiJ MGP_WSBEiJ_G0022890
 protein coding gene Chr17:34753424-34760601 (+)



Homology
more
  • Human Ortholog
    HSPA1L, heat shock protein family A (Hsp70) member 1 like
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA1L, heat shock protein family A (Hsp70) member 1 like
  • Synonyms
    HSP70-1L, HSP70-HOM, HSP70T, hum70t
  • Links
    NCBI Gene ID: 3305
    neXtProt AC: NX_P34931
    UniProt: P34931

  • Chr Location
    6p21.33; chr6:31809619-31815283 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human HSPA1L associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    46
  • cDNA Data
    6
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15482 NCBI Gene Model | MGI Sequence Detail 6526 C57BL/6J ±  kb
transcript NM_013558 RefSeq | MGI Sequence Detail 2415 ZRU/MplStud  
polypeptide P16627 UniProt | EBI | MGI Sequence Detail 641 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008806 heat shock 70 kDa protein 1-like
    (term hierarchy)
  • InterPro Domains
    IPR043129 ATPase, nucleotide binding domain
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 20
    Genomic 8
    cDNA 7
    Primer pair 4
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10942
References
more
  • Summaries
    All 60
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:10291 Matsumoto M, et al., Cloning of a hsp70-related gene expressed in mouse spermatids. Biochem Biophys Res Commun. 1990 Jan 15;166(1):43-9
  • Latest
    J:342696 Nakatsuka A, et al., A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease. Commun Biol. 2021 Mar 19;4(1):373
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory