About   Help   FAQ
Hal Gene Detail
Summary
  • Symbol
    Hal
  • Name
    histidine ammonia lyase
  • Synonyms
    histidase, Hsd
  • Feature Type
    protein coding gene
  • IDs
    MGI:96010
    NCBI Gene: 15109
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93324630-93352623 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.49 cM, cytoband C2-D1
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96010
 protein coding gene Chr10:93324630-93355166 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017651
 protein coding gene Chr10:94906630-94940562 (+)
A/J MGP_AJ_G0017630
 protein coding gene Chr10:91604132-91634414 (+)
AKR/J MGP_AKRJ_G0017588
 protein coding gene Chr10:94225582-94255946 (+)
BALB/cJ MGP_BALBcJ_G0017593
 protein coding gene Chr10:91871019-91903842 (+)
C3H/HeJ MGP_C3HHeJ_G0017416
 protein coding gene Chr10:94231029-94262577 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018050
 protein coding gene Chr10:98014630-98060280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015732
 protein coding gene Chr10:87202640-87231957 (+)
CAST/EiJ MGP_CASTEiJ_G0016981
 protein coding gene Chr10:94190615-94229609 (+)
CBA/J MGP_CBAJ_G0017385
 protein coding gene Chr10:102101347-102137355 (+)
DBA/2J MGP_DBA2J_G0017491
 protein coding gene Chr10:90701036-90732230 (+)
FVB/NJ MGP_FVBNJ_G0017483
 protein coding gene Chr10:89910322-89941908 (+)
LP/J MGP_LPJ_G0017565
 protein coding gene Chr10:95531797-95563778 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017514
 protein coding gene Chr10:103408330-103443483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018087
 protein coding gene Chr10:94111591-94145910 (+)
PWK/PhJ MGP_PWKPhJ_G0016762
 protein coding gene Chr10:90779881-90811426 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016550
 protein coding gene Chr10:92910753-92945423 (+)
WSB/EiJ MGP_WSBEiJ_G0017040
 protein coding gene Chr10:94087216-94121436 (+)



Homology
more
  • Human Ortholog
    HAL, histidine ammonia-lyase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAL, histidine ammonia-lyase
  • Synonyms
    HIS, HSTD
  • Links
    NCBI Gene ID: 3034
    neXtProt AC: NX_P42357
    UniProt: P42357

  • Chr Location
    12q23.1; chr12:95972662-95996365 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HAL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause elevated histidine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    55
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15109 NCBI Gene Model | MGI Sequence Detail 27994 C57BL/6J ±  kb
    transcript NM_010401 RefSeq | MGI Sequence Detail 2776 ZRU/MplStud  
    polypeptide P35492 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10611, MGD-MRK-10720, MGD-MRK-10944
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:5382 Kacser H, et al., Histidinaemic mutant in the mouse. Nature. 1973 Jul 13;244(5411):77-9
    • Latest
      J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory