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Gstm1 Gene Detail
Summary
  • Symbol
    Gstm1
  • Name
    glutathione S-transferase, mu 1
  • Synonyms
    Gstb1, Gstb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95860
    NCBI Gene: 14862
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:107919571-107925289 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.83 cM, cytoband F3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95860
 protein coding gene Chr3:107919566-107925289 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027762
 protein coding gene Chr3:109539012-109544784 (-)
A/J MGP_AJ_G0027722
 protein coding gene Chr3:106064963-106071087 (-)
AKR/J MGP_AKRJ_G0027687
 protein coding gene Chr3:108650776-108658533 (-)
BALB/cJ MGP_BALBcJ_G0027734
 protein coding gene Chr3:105759200-105768261 (-)
C3H/HeJ MGP_C3HHeJ_G0027464
 protein coding gene Chr3:108990288-108996478 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028178
 protein coding gene Chr3:113628243-113638094 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025516
 protein coding gene Chr3:102221908-102228177 (-)
CAST/EiJ MGP_CASTEiJ_G0026920
 protein coding gene Chr3:108371611-108377452 (-)
CBA/J MGP_CBAJ_G0027439
 protein coding gene Chr3:117493316-117498917 (-)
DBA/2J MGP_DBA2J_G0027581
 protein coding gene Chr3:105251293-105258331 (-)
FVB/NJ MGP_FVBNJ_G0027549
 protein coding gene Chr3:103137082-103143146 (-)
LP/J MGP_LPJ_G0027688
 protein coding gene Chr3:110961019-110967730 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027579
 protein coding gene Chr3:123556672-123577798 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028233
 protein coding gene Chr3:108244587-108250688 (-)
PWK/PhJ MGP_PWKPhJ_G0026646
 protein coding gene Chr3:104998274-105004432 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026466
 protein coding gene Chr3:106380385-106387001 (-)
WSB/EiJ MGP_WSBEiJ_G0027000
 protein coding gene Chr3:108771277-108779693 (-)



Homology
more
  • Human Ortholog
    GSTM1, glutathione S-transferase mu 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTM1, glutathione S-transferase mu 1
  • Synonyms
    GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1
  • Links
    NCBI Gene ID: 2944
    neXtProt AC: NX_P09488
    UniProt: P09488

  • Chr Location
    1p13.3; chr1:109687814-109709039 (+)  GRCh38
  • Human Ortholog
    GSTM5, glutathione S-transferase mu 5
  • Synonyms
    GSTM5-5, GTM5
  • Links
    NCBI Gene ID: 2949
    neXtProt AC: NX_P46439
    UniProt: P46439

  • Chr Location
    1p13.3; chr1:109711751-109775428 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gstm1 mouse models; 105 with human GSTM1,GSTM5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for the deletion of this gene display a reduced ability to metabolize 1,2-dichloro-4-nitrobenzene. Mice homozygous for a different knock-out allele exhibit abnormal behavior, altered response to valproic acid, and increased serotonin and dopamine levels in the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1005
  • Tissues
    117
  • cDNA Data
    12
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058135 Ensembl Gene Model | MGI Sequence Detail 5719 C57BL/6J ±  kb
transcript ENSMUST00000126593 Ensembl | MGI Sequence Detail 828 Not Applicable  
polypeptide ENSMUSP00000118874 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
    2.5.1.18
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR003081 Glutathione S-transferase, Mu class
    IPR004045 Glutathione S-transferase, N-terminal
    IPR040079 Glutathione transferase family
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
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  • All nucleic 20
    Genomic 5
    cDNA 12
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10314, MGD-MRK-10318
References
more
  • Summaries
    All 52
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:46014 Pearson WR, et al., Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA. J Biol Chem. 1983 Feb 10;258(3):2052-62
  • Latest
    J:330099 Li P, et al., Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice. FASEB J. 2022 Jun;36(6):e22373
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory