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Grn Gene Detail
Summary
  • Symbol
    Grn
  • Name
    granulin
  • Synonyms
    acrogranulin, epithelin, PC cell-derived growth factor, Pgrn, progranulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95832
    NCBI Gene: 14824
  • Alliance
  • Transcription Start Sites
    44 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:102321333-102327635 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.29 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95832
protein coding gene Chr11:102321141-102327874 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019235
protein coding gene Chr11:105407037-105413766 (+)
A/J MGP_AJ_G0019203
protein coding gene Chr11:100958303-100964996 (+)
AKR/J MGP_AKRJ_G0019172
protein coding gene Chr11:104075943-104082533 (+)
BALB/cJ MGP_BALBcJ_G0019177
protein coding gene Chr11:101440796-101448057 (+)
C3H/HeJ MGP_C3HHeJ_G0018986
protein coding gene Chr11:104282350-104290028 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019626
protein coding gene Chr11:108695289-108702043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017252
protein coding gene Chr11:98384693-98391187 (+)
CAST/EiJ MGP_CASTEiJ_G0018540
protein coding gene Chr11:105277499-105284363 (+)
CBA/J MGP_CBAJ_G0018955
protein coding gene Chr11:113179624-113189285 (+)
DBA/2J MGP_DBA2J_G0019067
protein coding gene Chr11:100472806-100479490 (+)
FVB/NJ MGP_FVBNJ_G0019057
protein coding gene Chr11:100005509-100012864 (+)
LP/J MGP_LPJ_G0019136
protein coding gene Chr11:105928306-105935051 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019088
protein coding gene Chr11:112679708-112686607 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019664
protein coding gene Chr11:104448756-104455910 (+)
PWK/PhJ MGP_PWKPhJ_G0018303
protein coding gene Chr11:101542367-101549054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018095
protein coding gene Chr11:104202172-104208796 (+)
WSB/EiJ MGP_WSBEiJ_G0018589
protein coding gene Chr11:104443548-104451919 (+)



Homology
more
  • Human Ortholog
    GRN, granulin precursor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRN, granulin precursor
  • Synonyms
    CLN11, GEP, GP88, PCDGF, PEPI, PGRN
  • Links
    NCBI Gene ID: 2896
    neXtProt AC: NX_P28799
    UniProt: P28799

  • Chr Location
    17q21.31; chr17:44345246-44353106 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Grn mouse models; 7 with human GRN associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    100 phenotypes from 9 alleles in 10 genetic backgrounds
    5 images
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some knock-out alleles display enhanced macrophage functions. Mice homozygous for another knock-out allele display reproductive and behavioral abnormalities. Mice homozygous for a third null allele display premature death and increased cellular aging. Heterozygosity for p.R504* mutation affects neural stem cells and leads to neurological defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14824 NCBI Gene Model | MGI Sequence Detail 6303 C57BL/6J ±  kb
    transcript NM_008175 RefSeq | MGI Sequence Detail 2148 ZRU/MplStud  
    polypeptide P28798 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 496
      Genomic 2
      cDNA 488
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10272
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 9
      Diseases 4
      Gene Ontology 20
      Phenotypes 133
    • Earliest
      J:4982 Baba T, et al., Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett. 1993 May 10;322(2):89-94
    • Latest
      J:344167 Sasaki T, et al., Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions. Biochem Biophys Res Commun. 2024 Jan 8;691:149341

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory