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Grik5 Gene Detail
Summary
  • Symbol
    Grik5
  • Name
    glutamate receptor, ionotropic, kainate 5 (gamma 2)
  • Synonyms
    GluRgamma2, KA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95818
    NCBI Gene: 14809
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24709274-24771771 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95818
 protein coding gene Chr7:24709274-24775421 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031852
 protein coding gene Chr7:23430786-23497380 (-)
A/J MGP_AJ_G0031831
 protein coding gene Chr7:22848656-22911836 (-)
AKR/J MGP_AKRJ_G0031760
 protein coding gene Chr7:23382561-23445574 (-)
BALB/cJ MGP_BALBcJ_G0031838
 protein coding gene Chr7:23051925-23115891 (-)
C3H/HeJ MGP_C3HHeJ_G0031557
 protein coding gene Chr7:23805385-23872036 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032300
 protein coding gene Chr7:24215613-24283152 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029355
 protein coding gene Chr7:24277474-24339115 (-)
CAST/EiJ MGP_CASTEiJ_G0030897
 protein coding gene Chr7:17280566-17344859 (-)
CBA/J MGP_CBAJ_G0031522
 protein coding gene Chr7:25099917-25173633 (-)
DBA/2J MGP_DBA2J_G0031676
 protein coding gene Chr7:22752521-22816110 (-)
FVB/NJ MGP_FVBNJ_G0031629
 protein coding gene Chr7:22740762-22805229 (-)
LP/J MGP_LPJ_G0031755
 protein coding gene Chr7:23740818-23810753 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031666
 protein coding gene Chr7:24834703-24906428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032332
 protein coding gene Chr7:23078605-23146553 (-)
PWK/PhJ MGP_PWKPhJ_G0030621
 protein coding gene Chr7:17682893-17745799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030452
 protein coding gene Chr7:14395434-14460649 (-)
WSB/EiJ MGP_WSBEiJ_G0031000
 protein coding gene Chr7:23249416-23317420 (-)



Homology
more
  • Human Ortholog
    GRIK5, glutamate ionotropic receptor kainate type subunit 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIK5, glutamate ionotropic receptor kainate type subunit 5
  • Synonyms
    EAA2, GluK5, GRIK2, KA2
  • Links
    NCBI Gene ID: 2901
    neXtProt AC: NX_Q16478
    UniProt: Q16478

  • Chr Location
    19q13.2; chr19:41998321-42070206 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRIK5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele display abnormal hippocampal synapse function. Mice homozygous for a second allele display decreased thermal nociception, increased startle response and increased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1069
  • Tissues
    143
  • cDNA Data
    67
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003378 Ensembl Gene Model | MGI Sequence Detail 62498 C57BL/6J ±  kb
    transcript ENSMUST00000003468 Ensembl | MGI Sequence Detail 3763 Not Applicable  
    polypeptide ENSMUSP00000003468 Ensembl | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008244 glutamate receptor ionotropic, kainate 5
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 69
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10256
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 11
      Gene Ontology 14
      Phenotypes 23
    • Earliest
      J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
    • Latest
      J:335422 Spirkova A, et al., Glutamate can act as a signaling molecule in mouse preimplantation embryos. Biol Reprod. 2022 Oct 11;107(4):916-927
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory