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Gnrh1 Gene Detail
Summary
  • Symbol
    Gnrh1
  • Name
    gonadotropin releasing hormone 1
  • Synonyms
    LHRH, LNRH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95789
    NCBI Gene: 14714
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67982717-67986889 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.66 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95789
 protein coding gene Chr14:67982630-67986889 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021506
 protein coding gene Chr14:62490264-62494460 (+)
A/J MGP_AJ_G0021465
 protein coding gene Chr14:60988443-60992639 (+)
AKR/J MGP_AKRJ_G0021441
 protein coding gene Chr14:63069268-63073464 (+)
BALB/cJ MGP_BALBcJ_G0021471
 protein coding gene Chr14:60983318-60987514 (+)
C3H/HeJ MGP_C3HHeJ_G0021248
 protein coding gene Chr14:62796714-62800910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021910
 protein coding gene Chr14:65327697-65331903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019450
 protein coding gene Chr14:58896932-58901388 (+)
CAST/EiJ MGP_CASTEiJ_G0020765
 protein coding gene Chr14:59295111-59299291 (+)
CBA/J MGP_CBAJ_G0021215
 protein coding gene Chr14:67336368-67340564 (+)
DBA/2J MGP_DBA2J_G0021338
 protein coding gene Chr14:60621418-60625614 (+)
FVB/NJ MGP_FVBNJ_G0021317
 protein coding gene Chr14:60026280-60030476 (+)
LP/J MGP_LPJ_G0021413
 protein coding gene Chr14:63543900-63548096 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021346
 protein coding gene Chr14:66314532-66318728 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021933
 protein coding gene Chr14:62300044-62304240 (+)
PWK/PhJ MGP_PWKPhJ_G0020509
 protein coding gene Chr14:57386716-57391006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020342
 protein coding gene Chr14:58243357-58247656 (+)
WSB/EiJ MGP_WSBEiJ_G0020818
 protein coding gene Chr14:62628917-62633113 (+)



Homology
more
  • Human Ortholog
    GNRH1, gonadotropin releasing hormone 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNRH1, gonadotropin releasing hormone 1
  • Synonyms
    GNRH, GRH, LHRH, LNRH
  • Links
    NCBI Gene ID: 2796
    neXtProt AC: NX_P01148
    UniProt: P01148

  • Chr Location
    8p21.2; chr8:25419258-25425040 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gnrh1 mouse models; 3 with human GNRH1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1198
  • Tissues
    175
  • cDNA Data
    14
  • Literature Summary
    139
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14714 NCBI Gene Model | MGI Sequence Detail 4173 C57BL/6J ±  kb
    transcript NM_008145 RefSeq | MGI Sequence Detail 487 C57BL/6  
    polypeptide P13562 UniProt | EBI | MGI Sequence Detail 90 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 4
      cDNA 14
      Primer pair 8
      Other 12

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10208, MGD-MRK-10915
    References
    more
    • Summaries
      All 361
      Developmental Gene Expression 139
      Diseases 1
      Gene Ontology 9
      Phenotypes 105
    • Earliest
      J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
    • Latest
      J:343285 Lettieri A, et al., SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability. Nat Commun. 2023 Dec 7;14(1):8097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory