About   Help   FAQ
Gnaz Gene Detail
Summary
  • Symbol
    Gnaz
  • Name
    guanine nucleotide binding protein, alpha z subunit
  • Synonyms
    Gz
  • Feature Type
    protein coding gene
  • IDs
    MGI:95780
    NCBI Gene: 14687
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:74803009-74852739 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95780
 protein coding gene Chr10:74803009-74852739 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017349
 protein coding gene Chr10:75099286-75150247 (+)
A/J MGP_AJ_G0017326
 protein coding gene Chr10:72525290-72576384 (+)
AKR/J MGP_AKRJ_G0017287
 protein coding gene Chr10:74461636-74512756 (+)
BALB/cJ MGP_BALBcJ_G0017286
 protein coding gene Chr10:72722581-72772994 (+)
C3H/HeJ MGP_C3HHeJ_G0017110
 protein coding gene Chr10:74509412-74560508 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017744
 protein coding gene Chr10:77767467-77820858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015434
 protein coding gene Chr10:68994723-69044833 (+)
CAST/EiJ MGP_CASTEiJ_G0016680
 protein coding gene Chr10:74816019-74867941 (+)
CBA/J MGP_CBAJ_G0017082
 protein coding gene Chr10:80817166-80869261 (+)
DBA/2J MGP_DBA2J_G0017187
 protein coding gene Chr10:71831537-71881954 (+)
FVB/NJ MGP_FVBNJ_G0017180
 protein coding gene Chr10:70972754-71025243 (+)
LP/J MGP_LPJ_G0017260
 protein coding gene Chr10:75589038-75641179 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017208
 protein coding gene Chr10:82939493-82993307 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017783
 protein coding gene Chr10:74496173-74549079 (+)
PWK/PhJ MGP_PWKPhJ_G0016464
 protein coding gene Chr10:71628956-71680214 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016247
 protein coding gene Chr10:73747894-73797575 (+)
WSB/EiJ MGP_WSBEiJ_G0016744
 protein coding gene Chr10:74460556-74513631 (+)



Homology
more
  • Human Ortholog
    GNAZ, G protein subunit alpha z
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAZ, G protein subunit alpha z
  • Synonyms
    gz-alpha, HG1H
  • Links
    NCBI Gene ID: 2781
    neXtProt AC: NX_P19086
    UniProt: P19086

  • Chr Location
    22q11.22-q11.23; chr22:23070519-23125032 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypertolerance to morphine. Mice homozygous for a reporter allele exhibit impaired platelet aggregation, increased resistance to fatal thromboembolism, reduced morphine-elicited antinociception, and altered behavioral responses to addictive substances.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    65
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14687 NCBI Gene Model | MGI Sequence Detail 49731 C57BL/6J ±  kb
    transcript NM_010311 RefSeq | MGI Sequence Detail 3605 C57BL/6  
    polypeptide O70443 UniProt | EBI | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008094 guanine nucleotide-binding protein G(z) subunit alpha
      (term hierarchy)
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10194, MGI:2143685
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338706 Schaid MD, et al., Agonist-independent Galphaz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes. J Biol Chem. 2021 Jan-Jun;296:100056
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory