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Fut4 Gene Detail
Summary
  • Symbol
    Fut4
  • Name
    fucosyltransferase 4
  • Synonyms
    3-fucosyl-N-acetyl-lactosamine epitope, FAL, FucT-IV, LeX, Ssea1, SSEA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95594
    NCBI Gene: 14345
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14659755-14663418 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 4.30 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95594
 protein coding gene Chr9:14659616-14663689 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034353
 protein coding gene Chr9:11701609-11705272 (-)
A/J MGP_AJ_G0034331
 protein coding gene Chr9:11647732-11651395 (-)
AKR/J MGP_AKRJ_G0034259
 protein coding gene Chr9:11660596-11664259 (-)
BALB/cJ MGP_BALBcJ_G0034325
 protein coding gene Chr9:11421725-11425388 (-)
C3H/HeJ MGP_C3HHeJ_G0034036
 protein coding gene Chr9:11956682-11960345 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034847
 protein coding gene Chr9:12085341-12089004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031785
 protein coding gene Chr9:10943624-10947289 (-)
CAST/EiJ MGP_CASTEiJ_G0033363
 protein coding gene Chr9:11794294-11797970 (-)
CBA/J MGP_CBAJ_G0034009
 protein coding gene Chr9:12652492-12656155 (-)
DBA/2J MGP_DBA2J_G0034166
 protein coding gene Chr9:11525747-11529410 (-)
FVB/NJ MGP_FVBNJ_G0034111
 protein coding gene Chr9:11118304-11121967 (-)
LP/J MGP_LPJ_G0034252
 protein coding gene Chr9:11800595-11804258 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034155
 protein coding gene Chr9:13695846-13699509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034866
 protein coding gene Chr9:11667239-11670901 (-)
PWK/PhJ MGP_PWKPhJ_G0033069
 protein coding gene Chr9:11583944-11588157 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032905
 protein coding gene Chr9:11759004-11762818 (-)
WSB/EiJ MGP_WSBEiJ_G0033479
 protein coding gene Chr9:11517419-11521248 (-)



Homology
more
  • Human Ortholog
    FUT4, fucosyltransferase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUT4, fucosyltransferase 4
  • Synonyms
    CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1
  • Links
    NCBI Gene ID: 2526
    neXtProt AC: NX_P22083
    UniProt: P22083

  • Chr Location
    11q21; chr11:94543921-94549895 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a modest increase in blood neutrophils, monocytes and eosinophils, and increased leukocyte rolling velocities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1176
  • Tissues
    272
  • cDNA Data
    13
  • Literature Summary
    118
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14345 NCBI Gene Model | MGI Sequence Detail 3664 C57BL/6J ±  kb
    transcript NM_010242 RefSeq | MGI Sequence Detail 3664 ZRU/MplStud  
    polypeptide Q11127 UniProt | EBI | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 13
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9894, MGI:2143062
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 118
      Gene Ontology 10
      Phenotypes 50
    • Earliest
      J:71489 Solter D, et al., Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U S A. 1978 Nov;75(11):5565-9
    • Latest
      J:340875 Zhou Z, et al., Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects. J Ovarian Res. 2023 Aug 10;16(1):160
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory