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Flg Gene Detail
Summary
  • Symbol
    Flg
  • Name
    filaggrin
  • Synonyms
    fillagrin, ft, profilaggrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95553
    NCBI Gene: 14246
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:93180853-93200996 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.16 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95553
 protein coding gene Chr3:93180830-93200996 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027532
 protein coding gene Chr3:93763341-93770469 (+)
A/J MGP_AJ_G0027497
 protein coding gene Chr3:90860490-90867271 (+)
AKR/J MGP_AKRJ_G0027465
 protein coding gene Chr3:92945792-92952545 (+)
BALB/cJ MGP_BALBcJ_G0027506
 protein coding gene Chr3:90608094-90614883 (+)
C3H/HeJ MGP_C3HHeJ_G0027244
 protein coding gene Chr3:93170502-93177283 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027949
 protein coding gene Chr3:97335831-97342621 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025297
 protein coding gene Chr3:87444042-87463615 (+)
CAST/EiJ MGP_CASTEiJ_G0026692
 protein coding gene Chr3:92604257-92613800 (+)
CBA/J MGP_CBAJ_G0027220
 protein coding gene Chr3:100712888-100721759 (+)
DBA/2J MGP_DBA2J_G0027357
 protein coding gene Chr3:90152395-90156963 (+)
FVB/NJ MGP_FVBNJ_G0027326
 protein coding gene Chr3:88281453-88288274 (+)
LP/J MGP_LPJ_G0027466
 protein coding gene Chr3:94998633-95005417 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027352
 protein coding gene Chr3:106978471-106986223 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028008
 protein coding gene Chr3:92682114-92688900 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026240
 protein coding gene Chr3:91019786-91026533 (+)
WSB/EiJ MGP_WSBEiJ_G0026774
 protein coding gene Chr3:93056262-93066924 (+)



Homology
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  • Gene Tree
    Flg
Human Diseases
more
  • Diseases
    1 with Flg mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 2 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene produce abnormalities in the skin of the ear, tail and dorsal trunk.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    49
  • cDNA Data
    8
  • Literature Summary
    145
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    • All Sequences
      61
    • RefSeq
      2
    • UniProt
      11
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14246 NCBI Gene Model | MGI Sequence Detail 20144 C57BL/6J ±  kb
    transcript AK137664 GenBank | ENA | DDBJ | MGI Sequence Detail 4523 C57BL/6J  
    polypeptide P11088 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 8
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9823, MGD-MRK-9881, MGI:2139967, MGI:95587
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 145
      Diseases 2
      Gene Ontology 9
      Phenotypes 44
    • Earliest
      J:5286 Lane PW, Two new mutations in linkage group XVI of the house mouse. Flaky tail and varitint-waddler-J. J Hered. 1972 May-Jun;63(3):135-40
    • Latest
      J:345520 Kaymak T, et al., IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut. 2023 May;72(5):821-833
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory