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Serpinb8 Gene Detail
Summary
  • Symbol
    Serpinb8
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 8
  • Synonyms
    CAP2, CAP-2, NK10, ovalbumin, Spi8
  • Feature Type
    protein coding gene
  • IDs
    MGI:894657
    NCBI Gene: 20725
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:107517668-107536708 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 50.34 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894657
 protein coding gene Chr1:107517668-107538214 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016384
 protein coding gene Chr1:109850923-109871381 (+)
A/J MGP_AJ_G0016364
 protein coding gene Chr1:106018821-106039269 (+)
AKR/J MGP_AKRJ_G0016328
 protein coding gene Chr1:108939459-108961658 (+)
BALB/cJ MGP_BALBcJ_G0016324
 protein coding gene Chr1:106119788-106139616 (+)
C3H/HeJ MGP_C3HHeJ_G0016151
 protein coding gene Chr1:109361050-109380824 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016783
 protein coding gene Chr1:114009305-114029818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014501
 protein coding gene Chr1:100130792-100147905 (+)
CAST/EiJ MGP_CASTEiJ_G0015734
 protein coding gene Chr1:108301087-108323934 (+)
CBA/J MGP_CBAJ_G0016123
 protein coding gene Chr1:117904874-117926874 (+)
DBA/2J MGP_DBA2J_G0016230
 protein coding gene Chr1:105041928-105063434 (+)
FVB/NJ MGP_FVBNJ_G0016229
 protein coding gene Chr1:103989095-104009078 (+)
LP/J MGP_LPJ_G0016303
 protein coding gene Chr1:111122152-111143253 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016256
 protein coding gene Chr1:122342431-122363887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016821
 protein coding gene Chr1:108932503-108956379 (+)
PWK/PhJ MGP_PWKPhJ_G0015519
 protein coding gene Chr1:104088156-104108615 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015307
 protein coding gene Chr1:107588201-107614475 (+)
WSB/EiJ MGP_WSBEiJ_G0015796
 protein coding gene Chr1:108828368-108848764 (+)



Homology
more
  • Human Ortholog
    SERPINB8, serpin family B member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB8, serpin family B member 8
  • Synonyms
    C18orf53, CAP2, PI8, PI-8, PSS5
  • Links
    NCBI Gene ID: 5271
    neXtProt AC: NX_P50452
    UniProt: P50452

  • Chr Location
    18q22.1; chr18:63970029-64019779 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SERPINB8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20725 NCBI Gene Model | MGI Sequence Detail 19041 C57BL/6J ±  kb
transcript NM_011459 RefSeq | MGI Sequence Detail 3075 C57BL/6  
polypeptide O08800 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 18

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory