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Ctla4 Gene Detail
Summary
  • Symbol
    Ctla4
  • Name
    cytotoxic T-lymphocyte-associated protein 4
  • Synonyms
    Cd152, Ctla-4, Ly-56
  • Feature Type
    protein coding gene
  • IDs
    MGI:88556
    NCBI Gene: 12477
  • Alliance
  • Transcription Start Sites
    12 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:60948184-60954991 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.58 cM, cytoband C
  • Mapping Data
    47 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88556
protein coding gene Chr1:60926159-60954991 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016080
protein coding gene Chr1:60966146-60996050 (+)
A/J MGP_AJ_G0016063
protein coding gene Chr1:58802075-58831826 (+)
AKR/J MGP_AKRJ_G0016019
protein coding gene Chr1:60460658-60498612 (+)
BALB/cJ MGP_BALBcJ_G0016018
protein coding gene Chr1:58839381-58873540 (+)
C3H/HeJ MGP_C3HHeJ_G0015850
protein coding gene Chr1:60698828-60733018 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016471
protein coding gene Chr1:63347104-63379047 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014192
protein coding gene Chr1:55010456-55039392 (+)
CAST/EiJ MGP_CASTEiJ_G0015432
protein coding gene Chr1:59912809-59947380 (+)
CBA/J MGP_CBAJ_G0015822
protein coding gene Chr1:65337673-65373736 (+)
DBA/2J MGP_DBA2J_G0015923
protein coding gene Chr1:58237894-58267756 (+)
FVB/NJ MGP_FVBNJ_G0015925
protein coding gene Chr1:57530068-57559171 (+)
LP/J MGP_LPJ_G0015995
protein coding gene Chr1:61839760-61872416 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015945
protein coding gene Chr1:68232651-68275058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016518
protein coding gene Chr1:60405648-60435182 (+)
PWK/PhJ MGP_PWKPhJ_G0015219
protein coding gene Chr1:57583071-57615249 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014999
protein coding gene Chr1:59893591-59929501 (+)
WSB/EiJ MGP_WSBEiJ_G0015495
protein coding gene Chr1:60083892-60114344 (+)



Homology
more
  • Human Ortholog
    CTLA4, cytotoxic T-lymphocyte associated protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTLA4, cytotoxic T-lymphocyte associated protein 4
  • Synonyms
    ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
  • Links
    NCBI Gene ID: 1493
    neXtProt AC: NX_P16410
    UniProt: P16410

  • Chr Location
    2q33.2; chr2:203853888-203873965 (+)  GRCh38

Human Diseases
more
  • Diseases
    43 with human CTLA4 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 6 alleles in 10 genetic backgrounds
    29 phenotypes from multigenic genotypes
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality at 3 to 4 weeks of age, decreased T cell numbers, abnormal T cell physiology, inflammation in mutliple organs, abnormal thymus morphology, and lymph node hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12477 NCBI Gene Model | MGI Sequence Detail 6808 C57BL/6J ±  kb
    transcript NM_009843 RefSeq | MGI Sequence Detail 1933 ZRU/MplStud  
    polypeptide P09793 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2224, MGD-MRK-2234
    References
    more
    • Summaries
      All 296
      Gene Ontology 7
      Phenotypes 129
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:340715 Guo M, et al., Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control. Cell Rep. 2023 Aug 30;42(9):113047

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory