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Csk Gene Detail
Summary
  • Symbol
    Csk
  • Name
    c-src tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88537
    NCBI Gene: 12988
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57533929-57560758 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.18 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88537
 protein coding gene Chr9:57533929-57560914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034874
 protein coding gene Chr9:56852010-56859594 (-)
A/J MGP_AJ_G0034855
 protein coding gene Chr9:55013230-55032374 (-)
AKR/J MGP_AKRJ_G0034784
 protein coding gene Chr9:56277659-56296685 (-)
BALB/cJ MGP_BALBcJ_G0034847
 protein coding gene Chr9:54798108-54805684 (-)
C3H/HeJ MGP_C3HHeJ_G0034557
 protein coding gene Chr9:56763086-56770542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035366
 protein coding gene Chr9:58433822-58455144 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032277
 protein coding gene Chr9:54316204-54336806 (-)
CAST/EiJ MGP_CASTEiJ_G0033878
 protein coding gene Chr9:56853017-56879421 (-)
CBA/J MGP_CBAJ_G0034528
 protein coding gene Chr9:60466319-60494042 (-)
DBA/2J MGP_DBA2J_G0034687
 protein coding gene Chr9:54880976-54888540 (-)
FVB/NJ MGP_FVBNJ_G0034629
 protein coding gene Chr9:54110038-54129719 (-)
LP/J MGP_LPJ_G0034770
 protein coding gene Chr9:57144366-57166533 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034672
 protein coding gene Chr9:61968204-61989092 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035388
 protein coding gene Chr9:56300244-56319257 (-)
PWK/PhJ MGP_PWKPhJ_G0033583
 protein coding gene Chr9:54911447-54931474 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033417
 protein coding gene Chr9:56592587-56614942 (-)
WSB/EiJ MGP_WSBEiJ_G0033991
 protein coding gene Chr9:56233769-56254360 (-)



Homology
more
  • Human Ortholog
    CSK, C-terminal Src kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSK, C-terminal Src kinase
  • Links
    NCBI Gene ID: 1445
    neXtProt AC: NX_P41240
    UniProt: P41240

  • Chr Location
    15q24.1; chr15:74782080-74803197 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 6 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    45
  • cDNA Data
    133
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12988 NCBI Gene Model | MGI Sequence Detail 26830 C57BL/6J ±  kb
    transcript NM_001411643 RefSeq | MGI Sequence Detail 2808 ZRU/MplStud  
    polypeptide P41241 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 1
      cDNA 135
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2195, MGI:2143301
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 16
      Gene Ontology 13
      Phenotypes 39
    • Earliest
      J:1184 Armstrong E, et al., The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. Cytogenet Cell Genet. 1992;60(2):119-20
    • Latest
      J:339002 Zhong X, et al., Inhibition of Src improves cardiac fibrosis in AngII-induced hypertrophy by regulating the expression of galectin-3. Microvasc Res. 2022 Jul;142:104347
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory