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Cd68 Gene Detail
Summary
  • Symbol
    Cd68
  • Name
    CD68 antigen
  • Synonyms
    gp110, Lamp4, macrosialin, Scard1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88342
    NCBI Gene: 12514
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69555039-69556979 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88342
 protein coding gene Chr11:69555039-69556996 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018545
 protein coding gene Chr11:70121119-70123059 (-)
A/J MGP_AJ_G0018513
 protein coding gene Chr11:67480229-67482169 (-)
AKR/J MGP_AKRJ_G0018482
 protein coding gene Chr11:69489006-69490946 (-)
BALB/cJ MGP_BALBcJ_G0018485
 protein coding gene Chr11:67789951-67791891 (-)
C3H/HeJ MGP_C3HHeJ_G0018298
 protein coding gene Chr11:69509568-69511508 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018936
 protein coding gene Chr11:72243978-72245918 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016581
 protein coding gene Chr11:64399701-64401633 (-)
CAST/EiJ MGP_CASTEiJ_G0017853
 protein coding gene Chr11:69760985-69762925 (-)
CBA/J MGP_CBAJ_G0018271
 protein coding gene Chr11:75478060-75480000 (-)
DBA/2J MGP_DBA2J_G0018380
 protein coding gene Chr11:67061236-67063176 (-)
FVB/NJ MGP_FVBNJ_G0018370
 protein coding gene Chr11:66698036-66699976 (-)
LP/J MGP_LPJ_G0018450
 protein coding gene Chr11:70688183-70690123 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018393
 protein coding gene Chr11:76071170-76073110 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018978
 protein coding gene Chr11:69752551-69754491 (-)
PWK/PhJ MGP_PWKPhJ_G0017627
 protein coding gene Chr11:67711657-67713597 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017417
 protein coding gene Chr11:69566269-69568211 (-)
WSB/EiJ MGP_WSBEiJ_G0017907
 protein coding gene Chr11:69424273-69426213 (-)



Homology
more
  • Human Ortholog
    CD68, CD68 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD68, CD68 molecule
  • Synonyms
    GP110, LAMP4, SCARD1
  • Links
    NCBI Gene ID: 968
    neXtProt AC: NX_P34810
    UniProt: P34810

  • Chr Location
    17p13.1; chr17:7579491-7582111 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced antigen presenting activity in dendritic cells in response to ovalbumin stimulation. Mice homozygous for another knock-out allele exhibit increased bone and dysfunctional osteoclasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    23
  • cDNA Data
    33
  • Literature Summary
    61
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018774 Ensembl Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
    transcript ENSMUST00000108654 Ensembl | MGI Sequence Detail 1008 Not Applicable  
    polypeptide ENSMUSP00000104294 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000002064 macrosialin
      (term hierarchy)
    • InterPro Domains
      IPR002000 Lysosome-associated membrane glycoprotein
      IPR048528 Lysosome-associated membrane glycoprotein 2-like, luminal domains
      IPR018134 Lysosome-associated membrane glycoprotein, conserved site
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 2
      cDNA 33
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1868
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 61
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344239 Wang Y, et al., BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development. Dev Cell. 2024 Jan 8;59(1):108-124.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory