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Ccne1 Gene Detail
Summary
  • Symbol
    Ccne1
  • Name
    cyclin E1
  • Synonyms
    CycE1, cyclin E
  • Feature Type
    protein coding gene
  • IDs
    MGI:88316
    NCBI Gene: 12447
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:37797409-37806915 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 25.35 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88316
 protein coding gene Chr7:37797409-37806959 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032100
 protein coding gene Chr7:37642475-37654388 (-)
A/J MGP_AJ_G0032080
 protein coding gene Chr7:36592618-36602462 (-)
AKR/J MGP_AKRJ_G0032013
 protein coding gene Chr7:37503955-37515649 (-)
BALB/cJ MGP_BALBcJ_G0032087
 protein coding gene Chr7:36905572-36915299 (-)
C3H/HeJ MGP_C3HHeJ_G0031804
 protein coding gene Chr7:38387727-38398497 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032564
 protein coding gene Chr7:39470989-39481229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029597
 protein coding gene Chr7:37303772-37313640 (-)
CAST/EiJ MGP_CASTEiJ_G0031139
 protein coding gene Chr7:29638463-29665619 (-)
CBA/J MGP_CBAJ_G0031772
 protein coding gene Chr7:40721061-40730596 (-)
DBA/2J MGP_DBA2J_G0031924
 protein coding gene Chr7:36426167-36435715 (-)
FVB/NJ MGP_FVBNJ_G0031877
 protein coding gene Chr7:36349896-36359557 (-)
LP/J MGP_LPJ_G0032001
 protein coding gene Chr7:37992919-38002485 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031917
 protein coding gene Chr7:39525472-39537145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032579
 protein coding gene Chr7:37111018-37120565 (-)
PWK/PhJ MGP_PWKPhJ_G0030861
 protein coding gene Chr7:29806978-29822616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030696
 protein coding gene Chr7:26668739-26678140 (-)
WSB/EiJ MGP_WSBEiJ_G0031249
 protein coding gene Chr7:37625128-37635242 (-)



Homology
more
  • Human Ortholog
    CCNE1, cyclin E1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCNE1, cyclin E1
  • Synonyms
    CCNE, pCCNE1
  • Links
    NCBI Gene ID: 898
    neXtProt AC: NX_P24864
    UniProt: P24864

  • Chr Location
    19q12; chr19:29811991-29824312 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CCNE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    38 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    86
  • cDNA Data
    64
  • Literature Summary
    140
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12447 NCBI Gene Model | MGI Sequence Detail 9507 C57BL/6J ±  kb
    transcript NM_007633 RefSeq | MGI Sequence Detail 2022 Not Specified  
    polypeptide Q61457 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 1
      cDNA 64
      Primer pair 11
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1828, MGI:2142245
    References
    more
    • Summaries
      All 249
      Developmental Gene Expression 140
      Gene Ontology 21
      Phenotypes 32
    • Earliest
      J:18661 Damjanov I, et al., Molecular cloning and characterization of murine cyclin E. Biochem Biophys Res Commun. 1994 Jun 15;201(2):994-1000
    • Latest
      J:343799 Katano W, et al., Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes. Development. 2023 Dec 15;150(24):dev201913
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory