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Bdnf Gene Detail
Summary
  • Symbol
    Bdnf
  • Name
    brain derived neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88145
    NCBI Gene: 12064
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:109505045-109557352 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 56.63 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88145
 protein coding gene Chr2:109505045-109557388 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026240
 protein coding gene Chr2:112013777-112067064 (+)
A/J MGP_AJ_G0026201
 protein coding gene Chr2:107324885-107377558 (+)
AKR/J MGP_AKRJ_G0026181
 protein coding gene Chr2:110340165-110392410 (+)
BALB/cJ MGP_BALBcJ_G0026210
 protein coding gene Chr2:107597053-107649357 (+)
C3H/HeJ MGP_C3HHeJ_G0025960
 protein coding gene Chr2:110629214-110682570 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026661
 protein coding gene Chr2:115669430-115721724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024047
 protein coding gene Chr2:102886110-102938070 (+)
CAST/EiJ MGP_CASTEiJ_G0025425
 protein coding gene Chr2:111130755-111184804 (+)
CBA/J MGP_CBAJ_G0025938
 protein coding gene Chr2:119682136-119733922 (+)
DBA/2J MGP_DBA2J_G0026076
 protein coding gene Chr2:106827382-106879729 (+)
FVB/NJ MGP_FVBNJ_G0026039
 protein coding gene Chr2:105743340-105808154 (+)
LP/J MGP_LPJ_G0026179
 protein coding gene Chr2:112197197-112250630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026063
 protein coding gene Chr2:123799629-123855706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026715
 protein coding gene Chr2:110489322-110542512 (+)
PWK/PhJ MGP_PWKPhJ_G0025160
 protein coding gene Chr2:106463432-106516119 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024960
 protein coding gene Chr2:109711491-109766141 (+)
WSB/EiJ MGP_WSBEiJ_G0025492
 protein coding gene Chr2:111244220-111298109 (+)



Homology
more
  • Human Ortholog
    BDNF, brain derived neurotrophic factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BDNF, brain derived neurotrophic factor
  • Synonyms
    ANON2, BULN2
  • Links
    NCBI Gene ID: 627
    neXtProt AC: NX_P23560
    UniProt: P23560

  • Chr Location
    11p14.1; chr11:27654893-27722058 (-)  GRCh38
Human Diseases
more
  • Diseases
    14 with human BDNF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    153 phenotypes from 21 alleles in 28 genetic backgrounds
    37 phenotypes from multigenic genotypes
    439 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null alleles exhibit sensory neuron losses affecting coordination, balance, hearing, taste, and breathing, cerebellar abnormalities, increased sympathetic neuron number, and postnatal lethality. Carriers show mild defects. Heterozygosity for a mutation that reduces levels of the mature form of the encoded peptide leads to depressive-like behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    168
  • cDNA Data
    14
  • Literature Summary
    115
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048482 Ensembl Gene Model | MGI Sequence Detail 52308 C57BL/6J ±  kb
    transcript ENSMUST00000111042 Ensembl | MGI Sequence Detail 3905 Not Applicable  
    polypeptide ENSMUSP00000106671 Ensembl | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 3
      cDNA 15
      Primer pair 14
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1534
    References
    more
    • Summaries
      All 833
      Developmental Gene Expression 115
      Diseases 1
      Gene Ontology 39
      Phenotypes 439
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:344220 Bai X, et al., Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice. J Neuroinflammation. 2024 Jan 9;21(1):15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory