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Adk Gene Detail
Summary
  • Symbol
    Adk
  • Name
    adenosine kinase
  • Synonyms
    2310026J05Rik, 5033405D03Rik, AK, MGC:6593
  • Feature Type
    protein coding gene
  • IDs
    MGI:87930
    NCBI Gene: 11534
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:21102642-21498637 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.58 cM, cytoband A2-B
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2828 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87930
 protein coding gene Chr14:21102622-21498637 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021051
 protein coding gene Chr14:13852987-14283329 (+)
A/J MGP_AJ_G0021000
 protein coding gene Chr14:13510538-13903855 (+)
AKR/J MGP_AKRJ_G0020977
 protein coding gene Chr14:14044877-14455788 (+)
BALB/cJ MGP_BALBcJ_G0021003
 protein coding gene Chr14:13613833-14011995 (+)
C3H/HeJ MGP_C3HHeJ_G0020787
 protein coding gene Chr14:13984520-14385975 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021436
 protein coding gene Chr14:14332918-14747411 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019004
 protein coding gene Chr14:13818306-14216501 (+)
CAST/EiJ MGP_CASTEiJ_G0020311
 protein coding gene Chr14:13769381-14192064 (+)
CBA/J MGP_CBAJ_G0020753
 protein coding gene Chr14:15067777-15519324 (+)
DBA/2J MGP_DBA2J_G0020876
 protein coding gene Chr14:13336421-13739728 (+)
FVB/NJ MGP_FVBNJ_G0020859
 protein coding gene Chr14:13225523-13630648 (+)
LP/J MGP_LPJ_G0020952
 protein coding gene Chr14:14066795-14490606 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020885
 protein coding gene Chr14:14831682-15270072 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021469
 protein coding gene Chr14:13835753-14244279 (+)
PWK/PhJ MGP_PWKPhJ_G0020060
 protein coding gene Chr14:12914228-13317381 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019882
 protein coding gene Chr14:13630016-14047401 (+)
WSB/EiJ MGP_WSBEiJ_G0020367
 protein coding gene Chr14:13821189-14228463 (+)



Homology
more
  • Human Ortholog
    ADK, adenosine kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADK, adenosine kinase
  • Synonyms
    AK
  • Links
    NCBI Gene ID: 132
    neXtProt AC: NX_P55263
    UniProt: P55263

  • Chr Location
    10q22; chr10:74151202-74709963 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adk mouse models; 1 with human ADK associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death before 14 days of age, growth retardation, liver abnormalities, apnea, and impaired temperature regulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1243
  • Tissues
    212
  • cDNA Data
    168
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039197 Ensembl Gene Model | MGI Sequence Detail 395996 C57BL/6J ±  kb
    transcript ENSMUST00000045376 Ensembl | MGI Sequence Detail 1782 Not Applicable  
    polypeptide ENSMUSP00000047665 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 168
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-1129, MGI:1916830, MGI:1923219, MGI:2145606, MGI:2145711
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 18
      Phenotypes 32
    • Earliest
      J:308489 Wong PC, et al., Purine ribonucleotide biosynthesis, interconversion and catabolism in mouse brain in vitro. Biochem J. 1972 Oct;129(5):1085-94
    • Latest
      J:342616 Gebril HM, et al., Developmental and foliation changes due to dysregulation of adenosine kinase in the cerebellum. Sci Rep. 2023 Nov 14;13(1):19831
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory