Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mavstm1Tsse
Name:	mitochondrial antiviral signaling protein; targeted mutation 1, Tsukasa Seya
MGI ID:	MGI:5558893
Gene:	Mavs  Location: Chr2:131075983-131089945 bp, + strand  Genetic Position: Chr2, 63.3 cM
Alliance:	Mavstm1Tsse page

Germline Transmission:	Earliest citation of germline transmission: J:179625
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exons 2 and 3. RT-PCR confirmed the absence of transcript expression. (J:179625)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mavs Mutation:	36 strains or lines available

Original:	J:179625 Oshiumi H, et al., The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. J Immunol. 2011 Nov 15;187(10):5320-7
All:	11 reference(s)