Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rhbdf1tm1.1Mfm
Name:	rhomboid 5 homolog 1; targeted mutation 1.1, Matthew Freeman
MGI ID:	MGI:5551620
Synonyms:	iRhom1-
Gene:	Rhbdf1  Location: Chr11:32159585-32172300 bp, - strand  Genetic Position: Chr11, 18.83 cM
Alliance:	Rhbdf1tm1.1Mfm page

Germline Transmission:	Earliest citation of germline transmission: J:203951
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 18. Cre-mediated recombination removed exons 2 through 18 and left the resistance cassette intact. (J:203951)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhbdf1 Mutation:	43 strains or lines available

Original:	J:203951 Christova Y, et al., Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. EMBO Rep. 2013 Oct;14(10):884-90
All:	2 reference(s)