Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp8tm1.1Raz
Name:	caspase 8; targeted mutation 1.1, Razqallah Hakem
MGI ID:	MGI:5546196
Gene:	Casp8  Location: Chr1:58834533-58886662 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Alliance:	Casp8tm1.1Raz page

Germline Transmission:	Earliest citation of germline transmission: J:82759
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Exons 3 and 4 were further removed by crossing with cre mice. (J:82759)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:	42 strains or lines available

Original:	J:82759 Salmena L, et al., Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 2003 Apr 1;17(7):883-95
All:	67 reference(s)