Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Wfikkn1tm1.1Sjl Name: WAP, FS, Ig, KU, and NTR-containing protein 1; targeted mutation 1.1, Sejin Lee MGI ID: MGI:5546193 Synonyms: Gasp2- Gene: Wfikkn1  Location: Chr17:26096602-26099832 bp, - strand  Genetic Position: Chr17, 12.97 cM Alliance: Wfikkn1tm1.1Sjl page

Axial skeleton patterning defects in Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl, Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl Fsttm1Zuk/Fsttm1Zuk, Gdf11tm1Sjl/Gdf11+ and Gdf11tm1Sjl/Gdf11tm1Sjl mice. Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:201148
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A Lox2272 site was inserted upstream of exon 2 and an FRT flanked neo cassette and Lox2272 site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. (J:201148)

Generation of the Wfikkn1tm1.1Sjl allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wfikkn1 Mutation:	15 strains or lines available

Original:	J:201148 Lee YS, et al., Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
All:	1 reference(s)