Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cishtm1.2Cdon
Name:	cytokine inducible SH2-containing protein; targeted mutation 1.2, Chen Dong
MGI ID:	MGI:5544427
Gene:	Cish  Location: Chr9:107173858-107179983 bp, + strand  Genetic Position: Chr9, 57.99 cM
Alliance:	Cishtm1.2Cdon page

Germline Transmission:	Earliest citation of germline transmission: J:204829
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted into exon 3 downstream of the coding sequence. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the coding sequence of exon 2 and 3. Western blot analysis confirmed the absence of protein expression on CD4+ T cells. (J:204829)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cish Mutation:	22 strains or lines available

Original:	J:204829 Yang XO, et al., The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul;14(7):732-40
All:	2 reference(s)