Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Capn6tm1Hiso Name: calpain 6; targeted mutation 1, Hiroyuki Sorimachi MGI ID: MGI:5544425 Gene: Capn6  Location: ChrX:142585232-142610408 bp, - strand  Genetic Position: ChrX, 64.83 cM, cytoband F2 Alliance: Capn6tm1Hiso page

Diameter of tongue muscle fibers is larger in Capn6tm1Hiso/Capn6tm1Hiso mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:200747
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ with a nuclear localization signal and flanked by a lox71 and a lox2272 site replaced exon 2 and was followed immediately by an inserted neomycin resistsance cassette. Absence of protein in E10.5 and E12.5 embryos was confirmed by Western blot analysis. (J:200747)

Generation of the Capn6tm1Hiso allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Capn6 Mutation:	9 strains or lines available

Original:	J:200747 Tonami K, et al., Calpain-6 deficiency promotes skeletal muscle development and regeneration. PLoS Genet. 2013 Aug;9(8):e1003668
All:	2 reference(s)