Eps8l2tm1Wma
Targeted Allele Detail
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Symbol: |
Eps8l2tm1Wma |
Name: |
EPS8-like 2; targeted mutation 1, Walter Marcotti |
MGI ID: |
MGI:5544327 |
Gene: |
Eps8l2 Location: Chr7:140918824-140942933 bp, + strand Genetic Position: Chr7, 86.66 cM
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Alliance: |
Eps8l2tm1Wma page
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Hair bundle abnormalities in hair cells from adult Eps8l2tm1Wma/Eps8l2tm1Wma mice
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:200669
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 16 and 17 were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in lungs from homozygous mice.
(J:200669)
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Generation of the Eps8l2tm1Wma allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Eps8l2 Mutation: |
37 strains or lines available
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Original: |
J:200669 Furness DN, et al., Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13898-903 |
All: |
1 reference(s) |
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