Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ednrbtm1.2Nat
Name:	endothelin receptor type B; targeted mutation 1.2, Jeremy Nathans
MGI ID:	MGI:5544085
Gene:	Ednrb  Location: Chr14:104052061-104081838 bp, - strand  Genetic Position: Chr14, 53.05 cM
Alliance:	Ednrbtm1.2Nat page

Germline Transmission:	Earliest citation of germline transmission: J:201133
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A LoxP site was inserted upstream of the start codon within the second exon of the targeted gene. A second LoxP site was placed downstream of the second exon, within the second intron. Recombinase mediated recombination removed the selection cassette and exon 2. (J:201133)

Generation of the Ednrbtm1.1Nat and Ednrbtm1.2Nat alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:	103 strains or lines available

Original:	J:201133 Rattner A, et al., Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
All:	1 reference(s)