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Spo11tm3Rdco
Targeted Allele Detail
Summary
Symbol: Spo11tm3Rdco
Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 3, R Daniel Camerini-Otero
MGI ID: MGI:5538689
Gene: Spo11  Location: Chr2:172819493-172835369 bp, + strand  Genetic Position: Chr2, 95.64 cM, cytoband H4
Alliance: Spo11tm3Rdco page
Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11tm1.1Gvpc/Spo11tm1.1Gvpc mice and absence of ovarian follicles in Spo11tm1.1Gvpc/Spo11tm3Rdco mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202231
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 2 through 6 were deleted. This allele results in the absence of protein expression. (J:202231)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spo11 Mutation:  20 strains or lines available
References
Original:  J:202231 Smagulova F, et al., Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele. BMC Genomics. 2013;14:493
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory