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Ampd3tm1Tm
Targeted Allele Detail
Summary
Symbol: Ampd3tm1Tm
Name: adenosine monophosphate deaminase 3; targeted mutation 1, Takayuki Morisak
MGI ID: MGI:5529271
Gene: Ampd3  Location: Chr7:110367413-110411612 bp, + strand  Genetic Position: Chr7, 57.85 cM, cytoband E2-E3
Alliance: Ampd3tm1Tm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203909
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted in exon 13. AMPD3 activity was found to be undetectable or extremely low in RBCs and the heart. (J:203909)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ampd3 Mutation:  37 strains or lines available
References
Original:  J:203909 Cheng J, et al., AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency. Genes Cells. 2012 Nov;17(11):913-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory