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Hoxdtm1.1Ssp
Targeted Allele Detail
Summary
Symbol: Hoxdtm1.1Ssp
Name: homeobox D cluster; targeted mutation 1.1, S Steven Potter
MGI ID: MGI:5522949
Synonyms: Hoxd9,10,11-
Gene: Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198638
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe BAC RP23-101K1 was used to sequentially targeted Hoxd9, Hoxd10, and Hoxd11. In all three genes a kan/neo cassette flanked by once only lox66 and lox71 was introduced into exon 1. This insertion introduced a small deletion/frameshift. In Hoxd9 and Hoxd10 the selection cassette was removed by cre mediated recombination before targeting of the subsequent gene. Thus only Hoxd11 retains the selection cassette in the final targeting vector and this was removed after targeting by cre mediated (J:198638)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 33 assay results
4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:  0 strains or lines available
Notes
es cells = SE2
References
Original:  J:198638 Raines AM, et al., Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Development. 2013 Jul;140(14):2942-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory