Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc9b2tm1.1Dgfu
Name:	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; targeted mutation 1.1, Daniel G Fuster
MGI ID:	MGI:5521370
Synonyms:	NHA2 KO
Gene:	Slc9b2  Location: Chr3:135013083-135048606 bp, + strand  Genetic Position: Chr3, 62.55 cM
Alliance:	Slc9b2tm1.1Dgfu page

Germline Transmission:	Earliest citation of germline transmission: J:197386
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo/Tk selection cassette was inserted upstream of exon 7 and a third loxP site was inserted downstream. The selection cassette and exon 7 were then excised from properly targeted ES cells by transient cre expression. Protein and mRNA were not detected in islets of knockout mice. (J:197386)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc9b2 Mutation:	45 strains or lines available

Original:	J:197386 Deisl C, et al., Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in beta-cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):10004-9
All:	3 reference(s)