Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Edn2tm1Ywa Name: endothelin 2; targeted mutation 1, Masashi Yanagisawa MGI ID: MGI:5519239 Synonyms: Edn2KO Gene: Edn2  Location: Chr4:120018403-120024557 bp, + strand  Genetic Position: Chr4, 55.77 cM Alliance: Edn2tm1Ywa page

Decreased body weight in Edn2tm1Ywa/Edn2tm1Ywa mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:201436
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced part of exon 1 and all of exon 2. RT-PCR confirmed the absence of transcript expression in the stomach, small intestine and colon. (J:201436)

Generation of the Edn2tm1Ywa allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Edn2 Mutation:	14 strains or lines available

Original:	J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All:	3 reference(s)