Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mterf1atm1.2Lrsn
Name:	mitochondrial transcription termination factor 1a; targeted mutation 1.2, Nils-Goran Larsson
MGI ID:	MGI:5514264
Gene:	Mterf1a  Location: Chr5:3940581-3943933 bp, - strand  Genetic Position: Chr5, 2.26 cM
Alliance:	Mterf1atm1.2Lrsn page

Germline Transmission:	Earliest citation of germline transmission: J:198969
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The second exon of Mterf1a was flanked by a loxP site and an FRT-flanked neomycin resistance cassette with a loxP site. The second exon of Mterf1b was replaced with a hygromycin resistance cassette. ES cells were selected for both mutations on the same chromosome. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the second exon of Mterf1a. Western blot analysis confirmed the absence of protein expression in the liver. (J:198969)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mterf1a Mutation:	21 strains or lines available

Original:	J:198969 Terzioglu M, et al., MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab. 2013 Apr 2;17(4):618-26
All:	1 reference(s)