Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scara5tm1Ktry
Name:	scavenger receptor class A, member 5; targeted mutation 1, Karl Tryggvason
MGI ID:	MGI:5510759
Gene:	Scara5  Location: Chr14:65903852-66002275 bp, + strand  Genetic Position: Chr14, 34.35 cM, cytoband D1
Alliance:	Scara5tm1Ktry page

Germline Transmission:	Earliest citation of germline transmission: J:195536
Parent Cell Line:	GSI-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3, which encodes the transmembrane domain, was replaced by the in-frame insertion of the EGFP coding sequence followed by a neomycin selection cassette in reverse orientation. The resulting EGFP fusion protein was unstable. No mRNA was detected in homozygous mice. (J:195536)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scara5 Mutation:	33 strains or lines available

Original:	J:195536 Ojala JR, et al., Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor a5-deficient mice. Am J Pathol. 2013 May;182(5):1681-95
All:	1 reference(s)