Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cgntm1.1Citi
Name:	cingulin; targeted mutation 1.1, Sandra Citi
MGI ID:	MGI:5508663
Gene:	Cgn  Location: Chr3:94667376-94693826 bp, - strand  Genetic Position: Chr3, 40.74 cM
Alliance:	Cgntm1.1Citi page

Germline Transmission:	Earliest citation of germline transmission: J:200284
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. The neomycin resistance cassette and exon 1 were removed via Cre-mediated recombination in the germline. Immunohistochemistry confirmed the absence of protein expression in epithelial tissues. (J:200284)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cgn Mutation:	58 strains or lines available

Original:	J:200284 Guillemot L, et al., Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012 Nov 1;125(Pt 21):5005-14
All:	2 reference(s)