Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cd68tm1.1Shnd
Name:	CD68 antigen; targeted mutation 1.1, Christian Schindler
MGI ID:	MGI:5506645
Gene:	Cd68  Location: Chr11:69555039-69556979 bp, - strand  Genetic Position: Chr11, 42.86 cM
Alliance:	Cd68tm1.1Shnd page

Germline Transmission:	Earliest citation of germline transmission: J:175275
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to place an rtTA (reverse tetracycline regulated transactivator) and a loxP-flanked neomycin resistance (neo) cassette downstream of the transcriptional start site. Correctly targeted mice were bred to cre expressing mice to delete the neo cassette and the resulting offspring were bred together to remove the cre-expressing transgene. (J:175275)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd68 Mutation:	34 strains or lines available

Original:	J:175275 Song L, et al., Deletion of the murine scavenger receptor CD68. J Lipid Res. 2011 Aug;52(8):1542-50
All:	3 reference(s)