Arhgef11tm1Sgkd
Targeted Allele Detail
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| Symbol: |
Arhgef11tm1Sgkd |
| Name: |
Rho guanine nucleotide exchange factor 11; targeted mutation 1, Silvio Gutkind |
| MGI ID: |
MGI:5505410 |
| Synonyms: |
Prg- |
| Gene: |
Arhgef11 Location: Chr3:87524866-87645341 bp, + strand Genetic Position: Chr3, 38.22 cM
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| Alliance: |
Arhgef11tm1Sgkd page
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Arhgef11tm1Sgkd/Arhgef11tm1Sgkd Arhgef12tm1Sgkd/Arhgef12tm1Sgkd embryos are less developed with partial branching failure of the cranial vessels
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:198274
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced exon 2 and 3. Western blot analysis confirmed the absence of protein expression in the cerebellum.
(J:198274)
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Generation of the Arhgef11tm1Sgkd allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Arhgef11 Mutation: |
75 strains or lines available
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| Original: |
J:198274 Mikelis CM, et al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26;288(17):12232-43 |
| All: |
2 reference(s) |
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Analysis Tools
