Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tdp2tm1.1Huy
Name:	tyrosyl-DNA phosphodiesterase 2; targeted mutation 1.1, Danny Huylebroeck
MGI ID:	MGI:5503302
Synonyms:	Tdp2delta1-3, Tdp2fldelta
Gene:	Tdp2  Location: Chr13:25015662-25026136 bp, + strand  Genetic Position: Chr13, 10.7 cM
Alliance:	Tdp2tm1.1Huy page

Germline Transmission:	Earliest citation of germline transmission: J:195301
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first three exons were flanked by loxP sites and an FRT and loxP flanked neomycin resistance cassette was inserted in intron 3. Properly targeted mice were crossed to cre expressing mice to excise exons 1-3 and the selection cassette. No protein activity was seen in protein extracts of cells from deleted mice. (J:195301)

Generation of the Tdp2tm1Huy and Tdp2tm1.1Huy alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Tdp2tm1.1Huy

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tdp2 Mutation:	25 strains or lines available

Original:	J:195301 Gomez-Herreros F, et al., TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet. 2013 Mar;9(3):e1003226
All:	4 reference(s)