Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plin2tm1.1Asg
Name:	perilipin 2; targeted mutation 1.1, Andrew Greenberg
MGI ID:	MGI:5502311
Synonyms:	Plin2delta5
Gene:	Plin2  Location: Chr4:86566623-86588297 bp, - strand  Genetic Position: Chr4, 40.69 cM
Alliance:	Plin2tm1.1Asg page

Germline Transmission:	Earliest citation of germline transmission: J:196302
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5. Western blot analysis confirmed the absence of protein expression in the liver of fed and fasted mice. (J:196302)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plin2 Mutation:	37 strains or lines available

Original:	J:196302 McManaman JL, et al., Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May;54(5):1346-59
All:	4 reference(s)