Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Extl2tm1Hkit
Name:	exostosin-like glycosyltransferase 2; targeted mutation 1, Hiroshi Kitagawa
MGI ID:	MGI:5502231
Gene:	Extl2  Location: Chr3:115801111-115822666 bp, + strand  Genetic Position: Chr3, 50.17 cM
Alliance:	Extl2tm1Hkit page

Germline Transmission:	Earliest citation of germline transmission: J:197845
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced part of exon 3 and all of exon 4. In situ hybridization confirmed the absence of transcript expression in E13 embryos. (J:197845)

Construction of the targeting vector to generate the Extl2tm1Hkit allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Extl2 Mutation:	16 strains or lines available

Original:	J:197845 Nadanaka S, et al., EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner. J Biol Chem. 2013 Mar 29;288(13):9321-33
All:	6 reference(s)