Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Srxn1tm1Mtol
Name:	sulfiredoxin 1 homolog (S. cerevisiae); targeted mutation 1, Mireille B Toledano
MGI ID:	MGI:5501480
Synonyms:	Srx-
Gene:	Srxn1  Location: Chr2:151947436-151953296 bp, + strand  Genetic Position: Chr2, 74.83 cM, cytoband H1
Alliance:	Srxn1tm1Mtol page

Germline Transmission:	Earliest citation of germline transmission: J:199277
Parent Cell Line:	AT1 (ES Cell)
Strain of Origin:	129S2/SvPasCrl

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in the liver. (J:199277)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Srxn1tm1Mtol

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srxn1 Mutation:	8 strains or lines available

Original:	J:199277 Planson AG, et al., Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock. Antioxid Redox Signal. 2011 Jun;14(11):2071-80
All:	5 reference(s)