Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myod1tm2.1Glh
Name:	myogenic differentiation 1; targeted mutation 2.1, David J Goldhamer
MGI ID:	MGI:5500170
Synonyms:	DRRloxP
Gene:	Myod1  Location: Chr7:46025898-46028516 bp, + strand  Genetic Position: Chr7, 30.03 cM
Alliance:	Myod1tm2.1Glh page

Germline Transmission:	Earliest citation of germline transmission: J:76260
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.9-kb genomic fragment containing the 714-bp downstream regulatory region was replaced with a PGKneo-positive selection cassette flanked by loxP sites. The neo selection cassette was subsequently removed by transient cre expression. Nothern blot analysis confirmed restored transcript expression levels. (J:76260)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

26 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myod1 Mutation:	23 strains or lines available

Original:	J:76260 Chen JC, et al., Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis. Dev Biol. 2002 May 1;245(1):213-23
All:	1 reference(s)