Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sirt2tm1.2Auw
Name:	sirtuin 2; targeted mutation 1.2, Johan Auwerx
MGI ID:	MGI:5499209
Synonyms:	Sirt2tm1.2Jmi
Gene:	Sirt2  Location: Chr7:28466192-28488086 bp, + strand  Genetic Position: Chr7, 16.92 cM, cytoband B1-2
Alliance:	Sirt2tm1.2Auw page

Germline Transmission:	Earliest citation of germline transmission: J:194977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 5 through 7 floxed. Cre-mediated recombination removed exons 5 through 7. Western blot analysis confirmed the absence of protein expression in the spinal cord, brain and sciatic nerve. (J:177468, J:194977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt2 Mutation:	25 strains or lines available

Original:	J:194977 Taes I, et al., Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum Mol Genet. 2013 May 1;22(9):1783-90
All:	5 reference(s)