Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Erftm2.1Gmav
Name:	Ets2 repressor factor; targeted mutation 2.1, George Mavrothalassitis
MGI ID:	MGI:5499178
Gene:	Erf  Location: Chr7:24941986-24950186 bp, - strand  Genetic Position: Chr7, 13.73 cM
Alliance:	Erftm2.1Gmav page

Germline Transmission:	Earliest citation of germline transmission: J:198059
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of the second coding exon. An additional loxP site was inserted downstream of the STOP codon in the fourth coding exon. Cre-mediated recombination removed the coding sequence between the loxP sites. (J:198059)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erf Mutation:	31 strains or lines available

Original:	J:198059 Twigg SR, et al., Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet. 2013 Mar;45(3):308-13
All:	1 reference(s)