Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pros1tm1.2Grl
Name:	protein S (alpha); targeted mutation 1.2, Greg Lemke
MGI ID:	MGI:5499100
Gene:	Pros1  Location: Chr16:62674670-62749709 bp, + strand  Genetic Position: Chr16, 36.43 cM
Alliance:	Pros1tm1.2Grl page

Germline Transmission:	Earliest citation of germline transmission: J:198769
Parent Cell Line:	2A (ES Cell)
Strain of Origin:	129S1/SvImJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 15. Cre-mediated recombination removed exons 11 through 15 and the neomycin resistance cassette. (J:198769)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pros1 Mutation:	44 strains or lines available

Original:	J:198769 Burstyn-Cohen T, et al., Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009 Oct;119(10):2942-53
All:	1 reference(s)