Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Krt1tm1Tmm
Name:	keratin 1; targeted mutation 1, Thomas M Magin
MGI ID:	MGI:5495252
Gene:	Krt1  Location: Chr15:101753861-101759221 bp, - strand  Genetic Position: Chr15, 57.06 cM
Alliance:	Krt1tm1Tmm page

Germline Transmission:	Earliest citation of germline transmission: J:197699
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Not Specified   Mutation details: The Hprt-mini cassette replaced exon 1, intron 1 and 415 bp of the 5' UTR. Western blot analysis confirmed the absence of protein in the skin. (J:200244)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt1 Mutation:	67 strains or lines available

Original:	J:197699 Wallace L, et al., Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. J Cell Sci. 2012 Apr 1;125(Pt 7):1750-8
All:	2 reference(s)