Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Agr2tm1.1Lex Name: anterior gradient 2; targeted mutation 1.1, Lexicon Genetics MGI ID: MGI:5494472 Gene: Agr2  Location: Chr12:36042924-36054080 bp, + strand  Genetic Position: Chr12, 16.18 cM Alliance: Agr2tm1.1Lex page

Mucosal hyperplasia in glandular stomach of Agr2tm1.1Lex/Agr2tm1.1Lex mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:195573
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exons 2 through 5. QRT-PCR confirmed the absence of transcript expression in the stomach. (J:195573)

Schematic of the Agr2tm1.1Lex allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agr2 Mutation:	31 strains or lines available

Original:	J:195573 Gupta A, et al., Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem. 2013 Feb 8;288(6):4321-33
All:	1 reference(s)