Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Panx1tm1.1Vshe
Name:	pannexin 1; targeted mutation 1.1, Valery I Shestopalov
MGI ID:	MGI:5487761
Gene:	Panx1  Location: Chr9:14917081-14956774 bp, - strand  Genetic Position: Chr9, 4.52 cM
Alliance:	Panx1tm1.1Vshe page

Germline Transmission:	Earliest citation of germline transmission: J:196355
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed the neo cassette and exons 3 and 4. Western blot analysis confirmed the absence of protein expression in the brain and retina. (J:196355)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Panx1 Mutation:	37 strains or lines available

Original:	J:196355 Dvoriantchikova G, et al., Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS One. 2012;7(2):e31991
All:	14 reference(s)