Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ubr4tm1.1Ytkw
Name:	ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.1, Yong Tae Kwon
MGI ID:	MGI:5487648
Gene:	Ubr4  Location: Chr4:139107970-139216844 bp, + strand  Genetic Position: Chr4, 70.66 cM
Alliance:	Ubr4tm1.1Ytkw page

Germline Transmission:	Earliest citation of germline transmission: J:196073
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 36 - 42 were replaced with an IRES-tau-LacZ cassette and a floxed tACE-Cre-Neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. (J:196073)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubr4 Mutation:	247 strains or lines available

Original:	J:196073 Tasaki T, et al., UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5
All:	3 reference(s)