Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tph2tm1Dmkh
Name:	tryptophan hydroxylase 2; targeted mutation 1, Donald M Kuhn
MGI ID:	MGI:5487385
Gene:	Tph2  Location: Chr10:114914546-115020927 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance:	Tph2tm1Dmkh page

Germline Transmission:	Earliest citation of germline transmission: J:196205
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neo cassette replaced 105 bp of exon 1. HPLC failed to detect enzymatic activity in the brain. (J:196205)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:	41 strains or lines available

Original:	J:196205 Thomas DM, et al., The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. J Neurochem. 2010 Nov;115(3):595-605
All:	8 reference(s)