Gjb6tm1.1Mcsa
Targeted Allele Detail
|
Symbol: |
Gjb6tm1.1Mcsa |
Name: |
gap junction protein, beta 6; targeted mutation 1.1, Martine Cohen-Salmon |
MGI ID: |
MGI:5486677 |
Synonyms: |
Cx30delta |
Gene: |
Gjb6 Location: Chr14:57360760-57371068 bp, - strand Genetic Position: Chr14, 30.1 cM
|
Alliance: |
Gjb6tm1.1Mcsa page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:193913
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 3 and a floxed pgk-hygromycin cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exon 3 and the pgk-hygromycin cassette. Quantitative PCR and western blot analysis indicate the absence of mRNA and protein expression in the inner ear of homozygous mice. Expression of Gjb2 mRNA and protein are reduced in the inner ear of homozygous mice but to a lesser extent than in mice homozygous for Gjb6tm1Kwi.
(J:193913)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Gjb6 Mutation: |
18 strains or lines available
|
|
Original: |
J:193913 Boulay AC, et al., Hearing is normal without connexin30. J Neurosci. 2013 Jan 9;33(2):430-4 |
All: |
5 reference(s) |
|