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Eps15tm1Noff
Targeted Allele Detail
Summary
Symbol: Eps15tm1Noff
Name: epidermal growth factor receptor pathway substrate 15; targeted mutation 1, Nina Offenhauser
MGI ID: MGI:5485036
Gene: Eps15  Location: Chr4:109137465-109245014 bp, + strand  Genetic Position: Chr4, 51.29 cM, cytoband C7
Alliance: Eps15tm1Noff page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195689
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the spleen. (J:195689)
Generation of the Eps15tm1Noff allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eps15 Mutation:  66 strains or lines available
References
Original:  J:195689 Pozzi B, et al., The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One. 2012;7(11):e50818
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory