Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nol3tm1.1Rnkt
Name:	nucleolar protein 3 (apoptosis repressor with CARD domain); targeted mutation 1.1, Richard N Kitsis
MGI ID:	MGI:5470099
Synonyms:	Nol3-
Gene:	Nol3  Location: Chr8:106002777-106008571 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Alliance:	Nol3tm1.1Rnkt page

Germline Transmission:	Earliest citation of germline transmission: J:193803
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the lungs. (J:193803)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nol3 Mutation:	9 strains or lines available

Original:	J:193803 Zaiman AL, et al., A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 2011 Dec 6;124(23):2533-42
All:	8 reference(s)